Early diabetic kidney maintains the corticomedullary urea and sodium gradient. Qi H, Nørlinger TS, Nielsen PM, Bertelsen LB, Mikkelsen E, Xu Y, Stødkilde Jørgensen H, Laustsen C. Physiol Rep. 2016 Mar;4(5). pii: e12714. doi: 10.14814/phy2.12714. PMID: 26997625

 

Hyperpolarized Renal Magnetic Resonance Imaging: Potential and Pitfalls. Laustsen C. Front Physiol. 2016 Mar 1;7:72. doi: 10.3389/fphys.2016.00072. eCollection 2016. Review. PMID: 26973539

 

Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13C,15N-urea. Bertelsen LB, Nielsen PM, Qi H, Nørlinger TS, Zhang X, Stødkilde-Jørgensen H, Laustsen C. 2016.

 

Glucagon infusion alters the hyperpolarized ¹³ C-urea renal hemodynamic signature. Qi H, Mariager CØ, Nielsen PM, Schroeder M, Lindhardt J, Nørregaard R, Klein JD, Sands JM,Laustsen C.

 

Hyperpolarized [1-¹³ C] pyruvate as a possible diagnostic tool in liver disease. Kjaergaard U, Laustsen C, Nørlinger T, Tougaard RS, Mikkelsen E, Qi H, Bertelsen LB, Jessen N, Stødkilde-Jørgensen H.

 

Acute hypertensive stress imaged by cardiac hyperpolarized [1-¹³ C]pyruvate magnetic resonance. Tougaard RS, Hansen ESS, Laustsen C, Lindhardt J, Schroeder M, Bøtker HE, Kim WY, Wiggers H, Stødkilde-Jørgensen H.Magn Reson Med. 2018 Nov;80(5):2053-2061. doi: 10.1002/mrm.27164. Epub 2018 Mar 9.PMID: 29524236

 

Evaluation of Active Brown Adipose Tissue by the Use of Hyperpolarized [1-¹³C]Pyruvate MRI in Mice. Riis-Vestergaard MJ, Breining P, Pedersen SB, Laustsen C, Stødkilde-Jørgensen H, Borghammer P, Jessen N, Richelsen B.Int J Mol Sci. 2018 Sep 1;19(9):2597. doi: 10.3390/ijms19092597.PMID: 30200469 Free PMC article.

 

Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-¹³C]Pyruvate MRI. Bertelsen LB, Nielsen PM, Qi H, Mariager CØ, Lindhardt J, Laustsen C.

 

Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI. Qi H, Mariager CØ, Lindhardt J, Nielsen PM, Stødkilde-Jørgensen H, Laustsen C.Magn Reson Med. 2018 Nov;80(5):2073-2080. doi: 10.1002/mrm.27165. Epub 2018 Mar 9.PMID: 29520870

 

Pilot Study Experiences With Hyperpolarized [1-¹³ C]pyruvate MRI in Pancreatic Cancer Patients. Stødkilde-Jørgensen H, Laustsen C, Hansen ESS, Schulte R, Ardenkjaer-Larsen JH, Comment A, Frøkiaer J, Ringgaard S, Bertelsen LB, Ladekarl M, Weber B.J Magn Reson Imaging. 2020 Mar;51(3):961-963. doi: 10.1002/jmri.26888. Epub 2019 Aug 1.PMID: 31368215 No abstract available.

 

Hyperpolarized [1-¹³ C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model. Tougaard RS, Szocska Hansen ES, Laustsen C, Nørlinger TS, Mikkelsen E, Lindhardt J, Nielsen PM, Bertelsen LB, Schroeder M, Bøtker HE, Kim WY, Wiggers H, Stødkilde-Jørgensen H.Magn Reson Med. 2019 Apr;81(4):2655-2665. doi: 10.1002/mrm.27560. Epub 2018 Nov 2.PMID: 30387898

PhD thesis

dDNP as a method to assess altered cellular metabolism in vitro. Malinowski, RM 2018,Technical University of Denmark

 

Journal Articles

Stable isotope-resolved analysis with quantitative dissolution dynamic nuclear polarization Lerche, MH, Yigit, D, Frahm, AB, Ardenkjær-Larsen, JH, Malinowski, RM & Jensen, PR 2018, '' Analytical Chemistry, vol 90, no. 1, pp. 674–678. DOI: 10.1021/acs.analchem.7b02779

Dissolution Dynamic Nuclear Polarization capability study with fluid path Malinowski, RM, Lipsø, HKW, Lerche, MH & Ardenkjær-Larsen, JH 2016, '' Journal of Magnetic Resonance, vol 272, pp. 141-146. DOI: 10.1016/j.jmr.2016.09.015 Submitted manuscript

 

 

PhD thesis

Effects of Coffee and Its Bioactive Compounds on Development and Progression of Type 2 Diabetes, Metabolic Syndrome, and Non-Alcoholic Fatty Liver Disease - Studies In-Vivo. Pedram Shokouh, November 2017   

  

Brown adipose tissue metabolism: Metabolic characterization and effect of betaadrenergic receptors - rodent and human adipocyte investigations. Mette Ji Riis-Vestergaard, Februar 2020   

  

Clinical aspects of hypoglycemia; studies in patients with type 1 diabetes, type 2 diabetes and healthy subjects. Mads Bisgaard Bengtsen, August 2020

 

Journal Articles

Sevoflurane Impairs Insulin Secretion and Tissue-Specific Glucose Uptake In Vivo. Høyer KF, Nielsen TS, Risis S, Treebak JT, Jessen N. Basic Clin Pharmacol Toxicol. 2018 Dec;123(6):732-738. doi: 10.1111/bcpt.13087. Epub 2018 Aug 24.

 

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity. Shi H, Munk A, Nielsen TS, Daughtry MR, Larsson L, Li S, Høyer KF, Geisler HW, Sulek K, Kjøbsted R, Fisher T, Andersen MM, Shen Z, Hansen UK, England EM, Cheng Z, Højlund K, Wojtaszewski JFP, Yang X, Hulver MW, Helm RF, Treebak JT, Gerrard DE. Mol Metab. 2018 May;11:160-177. doi: 10.1016/j.molmet.2018.02.010. Epub 2018 Feb 24.

 

Glucose metabolism in brown adipose tissue determined by deuterium metabolic imaging in rats. Riis-Vestergaard MJ, Laustsen C, Mariager CØ, Schulte RF, Pedersen SB, Richelsen B. Int J Obes (Lond). 2020 Jun;44(6):1417-1427. doi: 10.1038/s41366-020-0533-7. Epub 2020 Jan 21. PMDID: 31965069

 

Beta-1 and Not Beta-3 Adrenergic Receptors May Be the Primary Regulator of Human Brown Adipocyte Metabolism. Riis-Vestergaard MJ, Richelsen B, Bruun JM, Li W, Hansen JB, Pedersen SB. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz298. doi: 10.1210/clinem/dgz298.PMID: 31867674

Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice. Mellbye FB, Jeppesen PB, Shokouh P, Laustsen C, Hermansen K, Gregersen S. Journal of Natural Products, 05.05.2017.

 

A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome. Shokouh P, Jeppesen P B, Hermansen K, Nørskov N P, Laustsen C, Jacques Hamilton-Dutoit S, Qi H Stødkilde-Jørgensen H, Gregersen S. Nutrients, Bind 10, Nr. 1, 6, 01.2018.

 

A human randomized controlled trial comparing metabolic responses to single and repeated hypoglycemia in type 1 diabetes Bengtsen MB, Støy J, Rittig NF, Voss TS, Magnusson NE, Svart MV, Jessen N, Møller N. The Journal of Clinical Endocrinology & Metabolism, dgaa645, 09, 2020

 

Single shot three-dimensional pulse sequence for hyperpolarized ¹³C MRI. Wang J, Wright AJ, Hu D-E, Hesketh R, Brindle KM. Single shot three-dimensional pulse sequence for hyperpolarized ¹³C MRI. Magn Reson Med 2016:n/a-n/a  

 

Dynamic ¹H imaging of hyperpolarized [1-¹³C]lactate in vivo using a reverse INEPT experiment. Wang J, Kreis F, Wright AJ, Hesketh RL, Levitt MH, Brindle KM(2018) Magn. Reson. Med. 79, 741–747.  (Cover article).

 

A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-¹³C]pyruvate and [1-¹³C]lactate.  Wang JZ, Wright AJ, Hesketh RL, Hu DE, Brindle KM (2018) NMR Biomed. 31, 13

 

Hyperpolarized ¹³C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses. Wang JZ, Hesketh RL, Wright AJ, Brindle KM (2018) NMR in Biomedicine 31, e4004.

Cardiac dysfunction and metabolic inflexibility in a mouse model of diabetes without dyslipidaemia. Rohm M, Savic D, Ball V, Curtis MK, Bonham S, Fischer R, Legrave N, MacRae JI, Tyler DJ, Ashcroft FM.  Diabetes 2018.

 

Type 1 Diabetic Hearts show Unexpected Biphasic Metabolic and Functional Progression as Evaluated with Hyperpolarised [1-13C]Pyruvate and CINE MR. Savic D, Ball V, Carr C, Heather L, Tyler DJ. [In preparation]

 

L-carnitine show beneficial effects on cardiac metbaolism and function: A hyperpolarized MRS and Langendorff Perfusion Study. Savic D, Ball V, Curtis K, Timm K, Heather L, Tyler DJ. [In preparation]

 

In vivo hyperpolarized MRI reveal metabolic changes following treatment with mildronate in the control and diabetic heart. Savic D, Holzner L, Ball V, Curtis K, Heather L, Tyler DJ. [In preparation]