Early diabetic kidney maintains the corticomedullary urea and sodium gradient. Qi H, Nørlinger TS, Nielsen PM, Bertelsen LB, Mikkelsen E, Xu Y, Stødkilde Jørgensen H, Laustsen C. Physiol Rep. 2016 Mar;4(5). pii: e12714. doi: 10.14814/phy2.12714. PMID: 26997625
Hyperpolarized Renal Magnetic Resonance Imaging: Potential and Pitfalls. Laustsen C. Front Physiol. 2016 Mar 1;7:72. doi: 10.3389/fphys.2016.00072. eCollection 2016. Review. PMID: 26973539
Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13C,15N-urea. Bertelsen LB, Nielsen PM, Qi H, Nørlinger TS, Zhang X, Stødkilde-Jørgensen H, Laustsen C. 2016.
Glucagon infusion alters the hyperpolarized 13 C-urea renal hemodynamic signature. Qi H, Mariager CØ, Nielsen PM, Schroeder M, Lindhardt J, Nørregaard R, Klein JD, Sands JM,Laustsen C.
Hyperpolarized [1-13 C] pyruvate as a possible diagnostic tool in liver disease. Kjaergaard U, Laustsen C, Nørlinger T, Tougaard RS, Mikkelsen E, Qi H, Bertelsen LB, Jessen N, Stødkilde-Jørgensen H.
Acute hypertensive stress imaged by cardiac hyperpolarized [1-13 C]pyruvate magnetic resonance. Tougaard RS, Hansen ESS, Laustsen C, Lindhardt J, Schroeder M, Bøtker HE, Kim WY, Wiggers H, Stødkilde-Jørgensen H.Magn Reson Med. 2018 Nov;80(5):2053-2061. doi: 10.1002/mrm.27164. Epub 2018 Mar 9.PMID: 29524236
Evaluation of Active Brown Adipose Tissue by the Use of Hyperpolarized [1-13C]Pyruvate MRI in Mice. Riis-Vestergaard MJ, Breining P, Pedersen SB, Laustsen C, Stødkilde-Jørgensen H, Borghammer P, Jessen N, Richelsen B.Int J Mol Sci. 2018 Sep 1;19(9):2597. doi: 10.3390/ijms19092597.PMID: 30200469 Free PMC article.
Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-13C]Pyruvate MRI. Bertelsen LB, Nielsen PM, Qi H, Mariager CØ, Lindhardt J, Laustsen C.
Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI. Qi H, Mariager CØ, Lindhardt J, Nielsen PM, Stødkilde-Jørgensen H, Laustsen C.Magn Reson Med. 2018 Nov;80(5):2073-2080. doi: 10.1002/mrm.27165. Epub 2018 Mar 9.PMID: 29520870
Pilot Study Experiences With Hyperpolarized [1-13 C]pyruvate MRI in Pancreatic Cancer Patients. Stødkilde-Jørgensen H, Laustsen C, Hansen ESS, Schulte R, Ardenkjaer-Larsen JH, Comment A, Frøkiaer J, Ringgaard S, Bertelsen LB, Ladekarl M, Weber B.J Magn Reson Imaging. 2020 Mar;51(3):961-963. doi: 10.1002/jmri.26888. Epub 2019 Aug 1.PMID: 31368215 No abstract available.
Hyperpolarized [1-13 C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model. Tougaard RS, Szocska Hansen ES, Laustsen C, Nørlinger TS, Mikkelsen E, Lindhardt J, Nielsen PM, Bertelsen LB, Schroeder M, Bøtker HE, Kim WY, Wiggers H, Stødkilde-Jørgensen H.Magn Reson Med. 2019 Apr;81(4):2655-2665. doi: 10.1002/mrm.27560. Epub 2018 Nov 2.PMID: 30387898
Metabolic MRI with hyperpolarized [1-13C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke. Bøgh, N., Olin, R. B., Hansen, E. S. S., Gordon, J. W., Bech, S. K., Bertelsen, L. B., Sánchez-Heredia, J. D., Blicher, J. U., Østergaard, L., Ardenkjær-Larsen, J. H., Bok, R. A., Vigneron, D. B. & Laustsen, C. 2021, Journal of Cerebral Blood Flow and Metabolism. 41, 11, 12 p. Publikation: Bidrag til tidsskrift/ Tidsskriftartikel › Forskning › peer review
Di-chromatic interpolation of magnetic resonance metabolic images. Dwork, N., Gordon, J. W., Tang, S., O'Connor, D., Hansen, E. S. S., Laustsen, C. & Larson, P. E. Z., feb. 2021, I: Magnetic Resonance Materials in Physics, Biology and Medicine. 34, 1, s. 57-72 16 s. Publikation: Bidrag til tidsskrift/ Tidsskriftartikel › Forskning › peer review
MR er til meget mere end vand og fedt Vaeggemose, M., Bøgh, N., Ringgaard, S., Søvsø Szocska Hansen, E. & Laustsen, C., feb. 2022, I: Medicoteknik. 1, s. 16-19 4 s. Publikation: Bidrag til tidsskrift/ Tidsskriftartikel › Forskning › peer review
Hyperpolarized [1-13C]Pyruvate CMR and the potential of DMI at 3T. Christoffer Laustsen (Speaker) 6 marts 2020, Hyperpolarized Carbon-13 MRI Technology Development Workshop, UCSF, United States
Translation of hyperpolarized 13C Christoffer Laustsen (Speaker) 28 apr. 2021, ISMRM Nordic Chapter, virtuelt, internationalt
X-nucLei imaging - 13C, 2H and 23Na MRI. Christoffer Laustsen (Speaker), 31 maj 2021, Hvidovre Hospital, Denmark
Translation of hyperpolarized carbon-13 and deuterium imaging. Christoffer Laustsen (Speaker), 2 jun. 2021, CIL Isotope day, United States
Introduction to Tissue Oxygenation & Cellular Viability. Christoffer Laustsen (Speaker), 25 jul. 2021, EMIM 2021, Gôttingen, Deutchland
Working group 1 achievements. Christoffer Laustsen (Speaker), 11 sep. 2021, ISMRM workshop on renal MRI, Lisabon, Portugal
Considerations for translation of hyperpolarized [1-13C]pyruvate to clinical use. Christoffer Laustsen (Speaker), 28 sep. 2021, ISMRM International Society for Magnetic Resonance in Medicine
Multi center 13C studies are we ready for it? Christoffer Laustsen (Speaker), 21 okt. 2021
Evaluation of Cardiac and Renal Disease by Hyperpolarization. Christoffer Laustsen (Speaker) 11 jan. 2022, UT Southwestern Medical Center, Dallas, TX 2021
New neuro applications in Aarhus - future considerations Christoffer Laustsen (Speaker) 17 mar. 2022, UCSF, HMTRC konference, UCSF, San Fransisco
dDNP as a method to assess altered cellular metabolism in vitro. Malinowski, RM 2018,Technical University of Denmark
Stable isotope-resolved analysis with quantitative dissolution dynamic nuclear polarization Lerche, MH, Yigit, D, Frahm, AB, Ardenkjær-Larsen, JH, Malinowski, RM & Jensen, PR 2018, '' Analytical Chemistry, vol 90, no. 1, pp. 674–678. DOI: 10.1021/acs.analchem.7b02779
Dissolution Dynamic Nuclear Polarization capability study with fluid path Malinowski, RM, Lipsø, HKW, Lerche, MH & Ardenkjær-Larsen, JH 2016, '' Journal of Magnetic Resonance, vol 272, pp. 141-146. DOI: 10.1016/j.jmr.2016.09.015 Submitted manuscript
A new open-source quality assurance protocol for unbiased 13C coil comparison across sites. Olin, R. B., Hanson, L. G., Sanchez-heredia, J. D., McLean, M. A., Laustsen, C., Hansen, A. E., Hanson, L. G. & Ardenkjær-Larsen, J. H. 12 Aug. 2020 ISMRM, virtual conference, online
Flexible 8-Channel Array for Hyperpolarized 13C at 3T (32.1 MHz), with Nearly Identical 23Na (33.8 MHz) Sensitivity Pro -nucLei imaging - 13C, 2H and 23Na MRI. Sanchez, J. D., Wang, W., Grist, J. T., Søvsø Szocska Hansen, E., Laustsen, C., Zhurbenko, V. & Ardenkjær-Larsen, J. H., 20 maj 2021, 3 p, ISMRM, online
Effects of Coffee and Its Bioactive Compounds on Development and Progression of Type 2 Diabetes, Metabolic Syndrome, and Non-Alcoholic Fatty Liver Disease - Studies In-Vivo. Pedram Shokouh, November 2017
Brown adipose tissue metabolism: Metabolic characterization and effect of betaadrenergic receptors - rodent and human adipocyte investigations. Mette Ji Riis-Vestergaard, Februar 2020
Clinical aspects of hypoglycemia; studies in patients with type 1 diabetes, type 2 diabetes and healthy subjects. Mads Bisgaard Bengtsen, August 2020
Sevoflurane Impairs Insulin Secretion and Tissue-Specific Glucose Uptake In Vivo. Høyer KF, Nielsen TS, Risis S, Treebak JT, Jessen N. Basic Clin Pharmacol Toxicol. 2018 Dec;123(6):732-738. doi: 10.1111/bcpt.13087. Epub 2018 Aug 24.
Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity. Shi H, Munk A, Nielsen TS, Daughtry MR, Larsson L, Li S, Høyer KF, Geisler HW, Sulek K, Kjøbsted R, Fisher T, Andersen MM, Shen Z, Hansen UK, England EM, Cheng Z, Højlund K, Wojtaszewski JFP, Yang X, Hulver MW, Helm RF, Treebak JT, Gerrard DE. Mol Metab. 2018 May;11:160-177. doi: 10.1016/j.molmet.2018.02.010. Epub 2018 Feb 24.
Glucose metabolism in brown adipose tissue determined by deuterium metabolic imaging in rats. Riis-Vestergaard MJ, Laustsen C, Mariager CØ, Schulte RF, Pedersen SB, Richelsen B. Int J Obes (Lond). 2020 Jun;44(6):1417-1427. doi: 10.1038/s41366-020-0533-7. Epub 2020 Jan 21. PMDID: 31965069
Beta-1 and Not Beta-3 Adrenergic Receptors May Be the Primary Regulator of Human Brown Adipocyte Metabolism. Riis-Vestergaard MJ, Richelsen B, Bruun JM, Li W, Hansen JB, Pedersen SB. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz298. doi: 10.1210/clinem/dgz298.PMID: 31867674
Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice. Mellbye FB, Jeppesen PB, Shokouh P, Laustsen C, Hermansen K, Gregersen S. Journal of Natural Products, 05.05.2017.
A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome. Shokouh P, Jeppesen P B, Hermansen K, Nørskov N P, Laustsen C, Jacques Hamilton-Dutoit S, Qi H Stødkilde-Jørgensen H, Gregersen S. Nutrients, Bind 10, Nr. 1, 6, 01.2018.
A human randomized controlled trial comparing metabolic responses to single and repeated hypoglycemia in type 1 diabetes Bengtsen MB, Støy J, Rittig NF, Voss TS, Magnusson NE, Svart MV, Jessen N, Møller N. The Journal of Clinical Endocrinology & Metabolism, dgaa645, 09, 2020
Glucose metabolism in brown adipose tissue determined by deuterium metabolic imaging in rats Riis-Vestergaard, M. J., Laustsen, C., Mariager, C. Ø., Schulte, R. F., Pedersen, S. B. & Richelsen, B., jun. 2020, International journal of obesity. 44, 6, s. 1417-1427 11 s. Publikation: Bidrag til tidsskrift/ Tidsskriftartikel › Forskning › peer review
Beta-1 and not beta-3-adrenergic receptors may be the primary regulator of human brown adipocyte metabolism. Riis-Vestergaard, Mette Ji; Richelsen, Bjørn; Bruun, Jens Meldgaard; Li, Wei; Hansen, Jacob B; Pedersen, Steen Bønløkke. 2020, The Journal of clinical endocrinology and metabolism, Vol. 105, No. 4, dgz298. Publikation: Bidrag til tidsskrift/ Tidsskriftartikel › Forskning › peer review
Effects of whey protein and dietary fiber intake on insulin sensitivity, body composition, energy expenditure, blood pressure, and appetite in subjects with abdominal obesity. Fuglsang, Rasmus; Rakvaag, Elin; Langdahl, Bente Lomholt; Knudsen, Knud Erik Bach; Hartmann, Bolette; Holst, Jens Juul; Hermansen, Kjeld; Gregersen, Søren..2021, European Journal of Clinical Nutrition, Vol. 75, No. 4, 04. p. 611-619. Publikation: Bidrag til tidsskrift/ Tidsskriftartikel › Forskning › peer review
Hyperpolarized [1- 13C]pyruvate combined with the hyperinsulinaemic euglycaemic and hypoglycaemic clamp technique in skeletal muscle in a large animal model Bengtsen, M. B., Hansen, E. S. S., Tougaard, R. S., Lyhne, M. D., Rittig, N. F., Støy, J., Jessen, N., Mariager, C. Ø., Stødkilde-Jørgensen, H., Møller, N. & Laustsen, C., dec. 2021, Experimental Physiology. 106, 12, s. 2412-2422 11 s. Publikation: Bidrag til tidsskrift/ Tidsskriftartikel › Forskning › peer review
Single shot three-dimensional pulse sequence for hyperpolarized 13C MRI. Wang J, Wright AJ, Hu D-E, Hesketh R, Brindle KM. Single shot three-dimensional pulse sequence for hyperpolarized 13C MRI. Magn Reson Med 2016:n/a-n/a
Dynamic 1H imaging of hyperpolarized [1-13C]lactate in vivo using a reverse INEPT experiment. Wang J, Kreis F, Wright AJ, Hesketh RL, Levitt MH, Brindle KM(2018) Magn. Reson. Med. 79, 741–747. (Cover article).
A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13C]pyruvate and [1-13C]lactate. Wang JZ, Wright AJ, Hesketh RL, Hu DE, Brindle KM (2018) NMR Biomed. 31, 13
Hyperpolarized 13C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses. Wang JZ, Hesketh RL, Wright AJ, Brindle KM (2018) NMR in Biomedicine 31, e4004.
Cardiac dysfunction and metabolic inflexibility in a mouse model of diabetes without dyslipidaemia. Rohm M, Savic D, Ball V, Curtis MK, Bonham S, Fischer R, Legrave N, MacRae JI, Tyler DJ, Ashcroft FM. Diabetes 2018.
Type 1 Diabetic Hearts show Unexpected Biphasic Metabolic and Functional Progression as Evaluated with Hyperpolarised [1-13C]Pyruvate and CINE MR. Savic D, Ball V, Carr C, Heather L, Tyler DJ. [In preparation]
L-carnitine show beneficial effects on cardiac metbaolism and function: A hyperpolarized MRS and Langendorff Perfusion Study. Savic D, Ball V, Curtis K, Timm K, Heather L, Tyler DJ. [In preparation]
In vivo hyperpolarized MRI reveal metabolic changes following treatment with mildronate in the control and diabetic heart. Savic D, Holzner L, Ball V, Curtis K, Heather L, Tyler DJ. [In preparation]