Publications

Latest publications - 2025

Christensen NV , Liboriussen SE, Sanchez-Heredia JD, Hansen ESS , Laustsen C , Bertelsen LB. 30-Channel Microcoil System for High-Throughput Metabolic Flux Analysis Using Hyperpolarized 13C NMR Spectroscopy. NMR in Biomedicine. 2025 Oct;38(12):e70174. doi: 10.1002/nbm.70174

Zhao Y, Olin RB, Hansen ESS , Laustsen C, Hanson LG, Ardenkjær-Larsen JH. 3D quantitative myocardial perfusion imaging with hyperpolarized HP001(bis-1,1-(hydroxymethyl)-[1-¹³C]cyclopropane-d8): Application of gradient echo and balanced SSFP sequences. Magnetic Resonance in Medicine. 2025 Feb;93(2):814-827. doi: 10.1002/mrm.30320

Christensen NV , Redda M , Bøgh N , Søvsø Szocska Hansen E , Jespersen S , Laustsen C. A Combined Hemodynamic and Metabolic Exchange (HEMEX) Model for In Vivo Hyperpolarized 13C MRI. Magnetic Resonance in Medicine. 2025 Nov 18. Epub 2025 Nov 18. doi: 10.1002/mrm.70182

Young M, Aastrup M, Patel N, Cullen F, Hansen ESS, Clark JE et al. Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes. Scientific Reports. 2025 Nov;15(1):41382. doi: 10.1038/s41598-025-25314-8

Birchall JR, Wodtke P, Grimmer A, Hansen ESS , Bertelsen LB , Bøgh N et al. A pathway toward clinical translation of hyperpolarized [1,4-¹³C₂,2,3-d₂]fumarate as an imaging biomarker for early cellular necrosis in vivo. Magnetic Resonance in Medicine. 2025 Sept;94(3):1202-1217. Epub 2025. doi: 10.1002/mrm.30519

Bøgh N , Aastrup M , Mortensen JK , Gottrup H, Blicher JU, Borghammer P et al. Comparison of Deuterium Metabolic Imaging with FDG PET in Alzheimer Disease. Radiology. 2025 Apr;315(1):e241808. e241808. doi: 10.1148/radiol.241808

Punwani S, Larson PEZ, Laustsen C, VanderMeulen J, Ardenkjær-Larsen JH, Autry AW et al. Consensus recommendations for hyperpolarized [1-13C]pyruvate MRI multi-center human studies. Magnetic Resonance in Medicine. 2025 Oct;94(4):1386-1400. doi: 10.1002/mrm.30570

Mulbjerg H , Ringgaard S , Agger P. Diffusion tensor imaging reveals myocardial architectural differences between porcine and primate hearts with potential implications for cardiac xenotransplantation. Scientific Reports. 2025 Dec;15(1):28696. doi: 10.1038/s41598-025-14368-3

Aastrup M , Kjærgaard U , Laustsen C. Editorial for "Initial Experience of Metabolic Imaging With Hyperpolarized [1- 13C]pyruvate MRI in Kidney Transplant Patients". Journal of Magnetic Resonance Imaging. 2025 Apr;61(4):1979-1980. Epub 2024 Sept 7. doi: 10.1002/jmri.29582

Curtis MK, McGing JJ, Stubbs BJ, Ball V, Cochlin LE, O'Neill DP et al. Hyperpolarized 13C-MRS can Quantify Lactate Production and Oxidative PDH Flux in Murine Skeletal Muscle During Exercise. NMR in Biomedicine. 2025 May;38(5):e70020. e70020. doi: 10.1002/nbm.70020

Bontempi L, Zattoni M, Ramella A, Migliavacca F, Ringgaard S , Kim WY et al. Idealized aortic annuloplasty FSI digital twin of 3D-printed phantoms with 4D-flow MRI comparison. Computers in Biology and Medicine. 2025 Jun;192:110398. doi: 10.1016/j.compbiomed.2025.110398

Smith A, Miller JJ, Anthony DC, Radford-Smith DE. Machine learning-based prediction of anxiety disorders using blood metabolite and social trait data from the UK Biobank. Brain, Behavior, and Immunity - Health. 2025 Jul;46:101010. doi: 10.1016/j.bbih.2025.101010

Olsen NE, Mariager CØ, Arildsen MM, Nielsen S , Vendelbo MH , Pedersen M et al. Measurement of renal cortex perfusion: A direct comparison of arterial spin labelling magnetic resonance imaging and [¹⁵O]H₂O positron emission tomography. Magnetic Resonance in Medicine. 2025 Dec;94(6):2537-2549. doi: 10.1002/mrm.30638

Vaeggemose M , Kristensen MH , Redda M , Hansen ESS, Rodgers O, Collier GJ et al. MR Spectroscopic Imaging of Hyperpolarized 129-Xenon in the Dissolved-Phase to Determine Regional Chemical Shifts of Hyperoxia in Healthy Porcine Lungs. NMR in Biomedicine. 2025 Jun;38(6):e70063. doi: 10.1002/nbm.70063

Pasini S , Ringgaard S , Vendelboe T, Garcia-Ruiz L, Strittmatter A, Villa G et al. Multi-center and multi-vendor evaluation study across 1.5 T and 3 T scanners (part 1): apparent diffusion coefficient standardization in a diffusion MRI phantom. Magnetic Resonance Materials in Physics, Biology and Medicine. 2025 Jul;38(3):593-609. e1002203. doi: 10.1007/s10334-025-01256-0

Pasini S , Ringgaard S , Vendelboe T, Garcia-Ruiz L, Strittmatter A, Villa G et al. Multi-center and multi-vendor evaluation study across 1.5 T and 3 T scanners (part 2): T1 and T2 standardization in the ISMRM/NIST MR phantom. Magnetic Resonance Materials in Physics, Biology and Medicine. 2025 Jul;38(3):611-627. e0252966. Epub 2025. doi: 10.1007/s10334-025-01260-4

Thorsen TM , Bøgh N , Bertelsen LB , Hansen ESS , Laustsen C. Multinuclear MRI Can Depict Metabolic and Energetic Changes in Mild Traumatic Brain Injury. NMR in Biomedicine. 2025 Jan;38(1):e5306. doi: 10.1002/nbm.5306

Bech SK , Hansen ESS , Nielsen BR , Wiggers H , Bengtsen MB , Laustsen C et al. Myocardial metabolic flexibility following ketone infusion demonstrated by hyperpolarized [2- 13C]pyruvate MRS in pigs. Scientific Reports. 2025 Dec;15(1):5849. doi: 10.1038/s41598-025-90215-9

Kjaergaard U , Lund A , Redda M , Kristensen MH , Aastrup M , Bøgh N et al. Regional quantification of metabolic liver function using hyperpolarized [1-¹³C] pyruvate MRI. Scientific Reports. 2025 Dec;15(1):10482. doi: 10.1038/s41598-025-93725-8

Carter RD, Purnama U, Castro-Guarda M, Montes-Aparicio CN, Chandran A, Mbasu R et al. Systems Biology and Functional Assessments of Human iPSC-Cardiomyocyte Models of Insulin Resistance Capture Key Hallmarks of Diabetic Cardiomyopathy. Diabetes. 2025 Nov 1;74(11):1929-1945. Epub 2025 Sept 16. doi: 10.2337/db25-0204

Displaying results 1 to 20 out of 22

2024

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Rooney CHE, Lau JYC, Kennedy BWC, Bowen AM, Myers WK, Tullis IDC et al.. 6 MeV electron irradiated 13C-alanine as a sterile, transportable probe with long-lived radicals for dissolution Dynamic Nuclear Polarization. 2024. Abstract from 2024 ISMRM & ISMRT Annual Meeting & Exhibition, Singapore.

Christensen NV , Holm R, Sanchez JD, Hansen ESS, Lerche MH, Ardenkjaer-Larsen JH et al. A continuous flow bioreactor system for high-throughput hyperpolarized metabolic flux analysis. NMR in Biomedicine. 2024 May;37(5):e5107. e5107. doi: 10.1002/nbm.5107

Watson WD, Arvidsson PM, Miller JJJ, Lewis AJ, Rider OJ. A Mitochondrial Basis for Heart Failure Progression. Cardiovascular Drugs and Therapy. 2024 Dec;38(6):1161-1171. 790525. Epub 2024 Jun 15. doi: 10.1007/s10557-024-07582-0

Abood AA , Rölfing JD, Halloum A, Ringgaard S, Byskov JS, Kold S et al. An Innovative Plate Concept for Rotational Guided Growth: A Porcine Pilot Study. CUREUS. 2024 Apr;16(4):e58169. doi: 10.7759/cureus.58169

Kristensen MH , Vaeggemose M , Bøgh N , Søvsø Szocska Hansen E , Bendstrup E , Laustsen C. Characterising Regional Pulmonary Gas Transfer using Hyperpolarised 129-Xenon MRI in Fibrosing Interstitial Lung Disease. 2024. Abstract from ERS Congress 2024, Wien, Austria. doi: 10.1183/13993003.congress-2024.PA1644

Loci L, Lockyer SJ, Bennett TS, Rogers CJ, Brookfield A, Timco GA et al. Characterizing X-Ray and Solution State Conformations for a Model Qubit System: {Cr7Ni} Ring Rotaxanes on a Mixed Metal Triangle. Inorganic Chemistry. 2024 Dec 2;63(48):22880-22891. Epub 2024 Nov 17. doi: 10.1021/acs.inorgchem.4c03919

Andersen S, Laursen PH, Wood GJ , Lyhne MD , Madsen TL , Hansen ESS et al. Comparison of admittance and cardiac magnetic resonance generated pressure-volume loops in a porcine model. Physiological Measurement. 2024 May 1;45(5):055014. Epub 2024. doi: 10.1088/1361-6579/ad4a03

Larson PEZ, Bernard JML, Bankson JA, Bøgh N, Bok RA, Chen AP et al. Current methods for hyperpolarized [1-¹³C]pyruvate MRI human studies. Magnetic Resonance in Medicine. 2024 Jun;91(6):2204-2228. doi: 10.1002/mrm.29875

Rasmussen CW , Bøgh N , Ringgaard S , Birn H , Vaeggemose M, Schulte RF et al. Daytime Variation in Kidney Perfusion, Oxygenation, and Sodium Concentration Assessed by Multiparametric MRI in Healthy Volunteers. Journal of Magnetic Resonance Imaging. 2024 May;59(5):1603-1611. Epub 2023 Sept 1. doi: 10.1002/jmri.28983

Christensen NV , Laustsen C , Bertelsen LB. Differentiating leukemia subtypes based on metabolic signatures using hyperpolarized ¹³C NMR. NMR in Biomedicine. 2024 Dec;37(12):e5264. doi: 10.1002/nbm.5264

Jensen AE, Bjørn S , Nielsen TD, Moriggl B, Hoermann R, Vaeggemose M et al. Distal subsartorial compartment block of the saphenous nerve - A dissection study and a patient case series. Journal of Clinical Anesthesia. 2024 Feb;92:111315. doi: 10.1016/j.jclinane.2023.111315

Mellbye FD, Nguyen MD, Hermansen K , Jeppesen PB, Al-Mashhadi ZK, Ringgaard S et al. Effects of 12-Week Supplementation with Coffee Diterpene Cafestol in Healthy Subjects with Increased Waist Circumference: A Randomized, Placebo-Controlled Trial. Nutrients. 2024 Oct;16(19):3232. doi: 10.3390/nu16193232

Andersen S , Axelsen JS , Nielsen-Kudsk AH , Schwab J , Jensen CD , Ringgaard S et al. Effects of dopamine β-hydroxylase inhibition in pressure overload-induced right ventricular failure. Pulmonary Circulation. 2024 Oct;14(4):e70008. e70008. doi: 10.1002/pul2.70008

Gaemelke T , Laustsen C, Feys P, Folkestad L, Andersen MS, Jørgensen NR et al. Effects of power training in older patients with multiple sclerosis on neurodegeneration, neuromuscular function, and physical function: A study protocol for the "power training in older multiple sclerosis patients (PoTOMS) randomized control trial. Contemporary Clinical Trials Communications. 2024 Apr;38:101279. doi: 10.1016/j.conctc.2024.101279

Vernstrøm L , Gullaksen S , Sørensen SS , Ringgaard S , Laustsen C , Birn H et al. Effects of semaglutide, empagliflozin and their combination on renal diffusion-weighted MRI and total kidney volume in patients with type 2 diabetes: a post hoc analysis from a 32 week randomised trial. Diabetologia. 2024 Oct;67(10):2175-2187. Epub 2024 Jul 30. doi: 10.1007/s00125-024-06228-y

Shinozaki A, Sanchez-Heredia JD, Andersen MP , Redda M , Dang DA , Hansen ESS et al. Enabling SENSE accelerated 2D CSI for hyperpolarized carbon-13 imaging. Scientific Reports. 2024 Sept;14(1):20591. doi: 10.1038/s41598-024-70892-8

Aastrup M, Liu X, Lykkegaard E, Bøgh N , Kjærgaard U , Redda M et al.. Estimation of T2* values in hyperpolarized 13C MRI of healthy and ischemic kidneys in a porcine model. 2024.

Arildsen MM , Mariager CØ , Overgaard CV , Vorre T , Bøjesen M , Moeslund N et al. Ex Vivo Simultaneous H₂¹⁵O Positron Emission Tomography and Magnetic Resonance Imaging of Porcine Kidneys—A Feasibility Study. Journal of Imaging. 2024 Sept;10(9):209. doi: 10.3390/jimaging10090209

Andelius TCK , Hansen ESS , Bøgh N , Pedersen MV , Kyng KJ , Henriksen TB et al. Hyperpolarized ^13 C magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: First investigations in a large animal model. NMR in Biomedicine. 2024 May;37(5):e5110. e5110. doi: 10.1002/nbm.5110

Joergensen SH , Hansen ESS , Bøgh N , Bertelsen LB , Tougaard RS, Staehr PB et al. Hyperpolarized [1- ¹³C]pyruvate cardiovascular magnetic resonance imaging identifies metabolic phenotypes in patients with heart failure. Journal of Cardiovascular Magnetic Resonance. 2024 Dec 1;26(2):101095. Epub 2024 Sept 11. doi: 10.1016/j.jocmr.2024.101095

Displaying results 1 to 20 out of 39

2023

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Wang W, Sánchez-Heredia JD, Olin RB, Hansen ESS , Laustsen C, Zhurbenko V et al. A cryogenic 14-channel 13 C receiver array for 3T human head imaging. Magnetic Resonance in Medicine. 2023 Mar;89(3):1265-1277. doi: 10.1002/mrm.29508

Maagaard M , Boutrup N , Udholm S, Ahlstrup M, Nielsen-Kudsk JE , Ringgaard S et al. Adults with small, unrepaired atrial septal defects have reduced cardiac index during exercise. Cardiology in the Young. 2023 Oct 5;33(10):1981-1991. Epub 2022 Dec. doi: 10.1017/S1047951122003742

Vaeggemose M, Schulte RF, Hansen ESS , Miller J , Rasmussen CW, Pilgrim-Morris JH et al. A Framework for Predicting X-Nuclei Transmitter Gain Using ¹H Signal. Tomography - A Journal for Imaging Research. 2023 Oct;9(5):1603-1616. doi: 10.3390/tomography9050128

Radford-Smith DE, Anthony DC, Benz F, Grist JT, Lyman M, Miller JJ et al. A multivariate blood metabolite algorithm stably predicts risk and resilience to major depressive disorder in the general population. EBioMedicine. 2023 Jul;93:104643. doi: 10.1016/j.ebiom.2023.104643

Lauridsen MH , Uldbjerg N, Peters DA, Ringgaard S , Hjortdal VE. A short session of maternal hyperoxygenation ameliorates the cerebral oxygenation difference between fetuses with and without congenital heart defects. Global Pediatrics. 2023 Jun;4:100052. doi: 10.1016/j.gpeds.2023.100052

Hundertmark MJ, Adler A, Antoniades C, Coleman R, Griffin JL, Holman RR et al. Assessment of Cardiac Energy Metabolism, Function, and Physiology in Patients With Heart Failure Taking Empagliflozin: The Randomized, Controlled EMPA-VISION Trial. Circulation. 2023 May;147(22):1654-1669. doi: 10.1161/CIRCULATIONAHA.122.062021

Kjaergaard U , Bøgh N , Hansen ESS , Tougaard RS , Bertelsen LB, Schulte RF et al. Assessment of focal renal ischemia-reperfusion injury in a porcine model using hyperpolarized [1-¹³ C]pyruvate MRI. Magnetic Resonance in Medicine. 2023 Aug;90(2):655-663. doi: 10.1002/mrm.29649

Kjærgaard U , Ye Z , Søvsø Szocska Hansen E , Redda M , Eriksen PL , Vilstrup HVA et al.. Assessment of porcine liver metabolism after alanine infusion using hyperpolarized [1-13C]pyruvate MRI. 2023.

Christensen NV , Vaeggemose M , Bøgh N , Hansen ESS , Olesen JL, Kim Y et al. A user independent denoising method for x-nuclei MRI and MRS. Magnetic Resonance in Medicine. 2023 Dec;90(6):2539-2556. doi: 10.1002/mrm.29817

Vaeggemose M, Schulte RF, Laustsen C. Clinically feasible B1 field correction for multi-organ sodium imaging at 3T. NMR in Biomedicine. 2023 Feb;36(2):e4835. Epub 2022 Sept 17. doi: 10.1002/nbm.4835

Andelius TCK , Seiersen KV , Hansen LH , Larsen SS , Pedersen MV, Andersen M et al.. Comparison of semi-LASER vs. PRESS for acquisition of 1H MRS in newborn piglets with HIE.. 2023.

Tyler A, Ellis J, Lau JYC, Miller JJ, Bottomley PA, Rodgers CT et al. Compartment-based reconstruction of 3D acquisition-weighted ³¹P cardiac magnetic resonance spectroscopic imaging at 7 T: A reproducibility study. NMR in Biomedicine. 2023 Sept;36(9):e4950. Epub 2023 Apr 12. doi: 10.1002/nbm.4950

Tyler A, Hundertmark MJ, Miller JJ, Rider O, Tyler DJ, Valkovič L. Compartment-based reconstruction of acquisition-weighted ³¹P cardiac MRSI reduces sensitivity to cardiac motion and scan planning. Frontiers in Physiology. 2023;14:1325458. doi: 10.3389/fphys.2023.1325458

Sejersen S , Rasmussen CW , Bøgh N , Kjaergaard U , Hansen ESS, Schulte RF et al. Considering whole-body metabolism in hyperpolarized MRI through ¹³C breath analysis-An alternative way to quantification and normalization? Magnetic Resonance in Medicine. 2023 Aug;90(2):664-672. doi: 10.1002/mrm.29669

Redda M , Bøgh NH , Laustsen C, Schulte R, Søvsø Szocska Hansen E. Cyclic changes in myocardial metabolism revealed by adenosine stress test and hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance. 2023.

Grist JT, Bøgh N , Søvsø Szocska Hansen E, Schneider A, Healicon R, Ball V et al. Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging. Scientific Reports. 2023 Jan;13(1):1613. doi: 10.1038/s41598-023-28643-8

Andelius TCK , Bøgh N , Pedersen MV , Omann C , Andersen M , Andersen HB et al. Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets. Frontiers in Pediatrics. 2023 Jul 10;11:1167396. doi: 10.3389/fped.2023.1167396

Arlien-Søborg MC , Madsen MA , Dal J , Krusenstjerna-Hafstrøm T , Ringgaard S, Skou N et al. Ectopic lipid deposition and insulin resistance in patients with GH disorders before and after treatment. European Journal of Endocrinology. 2023 Jan;188(1):78-85. doi: 10.1093/ejendo/lvac014

Axelsen JS, Nielsen-Kudsk AH , Schwab J , Ringgaard S , Nielsen-Kudsk JE, de Man FS et al. Effects of empagliflozin on right ventricular adaptation to pressure overload. Frontiers in Cardiovascular Medicine. 2023 Dec;10:1302265. doi: 10.3389/fcvm.2023.1302265

Andersen HB , Andersen M , Andelius TCK , Pedersen MV , Løfgren B , Pedersen M et al. Epinephrine vs placebo in neonatal resuscitation: ROSC and brain MRS/MRI in term piglets. Pediatric Research. 2023 Feb;93(3):511-519. Epub 2022 Jun 9. doi: 10.1038/s41390-022-02126-4

Displaying results 1 to 20 out of 36

2022

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Uhrenholt L , Brix L , Wichmann TO , Pedersen M , Ringgaard S , Jensen TS. Advanced magnetic resonance imaging of chronic whiplash patients: a clinical practice-based feasibility study. Chiropractic & Manual Therapies. 2022 Dec;30(1):2. doi: 10.1186/s12998-022-00410-y

Andersen OM , Bøgh N , Landau AM , Pløen GG , Jensen AMG , Monti G et al. A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency. Cell Reports Medicine. 2022 Sept;3(9):100740. Epub 2022 Sept 8. doi: 10.1016/j.xcrm.2022.100740

Jensen JB , Dollerup OL , Møller AB , Billeskov TB, Dalbram E, Chubanava S et al. A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals. JCI Insight. 2022 Oct;7(19):e158314. Epub 2022 Aug 23. doi: 10.1172/jci.insight.158314

Healicon R, Rooney CHE, Ball V, Shinozaki A, Miller JJ, Smart S et al. Assessing the effect of anesthetic gas mixtures on hyperpolarized ¹³C pyruvate metabolism in the rat brain. Magnetic Resonance in Medicine. 2022 Sept;88(3):1324-1332. Epub 2022 Apr 25. doi: 10.1002/mrm.29274

Lauridsen H, Hyllested Pedersen JM, Ringgaard S, Møller PR. Buoyancy and hydrostatic balance in a West Indian Ocean coelacanth Latimeria chalumnae. BMC Biology. 2022 Dec;20(180):180. doi: 10.1186/s12915-022-01354-8

Lauridsen H, Pedersen JMH, Ringgaard S, Møller PR. Buoyancy and Hydrostatic Balance in The West Indian Coelacanth Latimeria chalumnae. The FASEB Journal. 2022 May;36(S1). doi: 10.1096/fasebj.2022.36.S1.0R901

Wood G , Kirkevang TS , Agergaard J , Leth S , Hansen ESS , Laustsen C et al. Cardiac Performance and Cardiopulmonary Fitness After Infection With SARS-CoV-2. Frontiers in Cardiovascular Medicine. 2022 May 13;9:871603. doi: 10.3389/fcvm.2022.871603

Miller J, Heather L. Cardiometabolic risk factors vary with age differently in females and males. Nature Cardiovascular Research. 2022 Sept;1(9):796–797 . doi: 10.1038/s44161-022-00130-9

Vammen L , Munch Johannsen C , Magnussen A , Povlsen AL , Riis Petersen S, Azizi A et al. Cerebral monitoring in a pig model of cardiac arrest with 48 h of intensive care. Intensive Care Medicine Experimental. 2022 Oct;10(1):45. doi: 10.1186/s40635-022-00475-2

Seiersen KV , Brogård Andersen H , Andersen M , Andelius TCK , Pedersen MV , Hansen LH et al. Cerebral MRI and MRS in newborn piglets with and without seizures in a lipopolysaccharide-sensitized hypoxic cardiac arrest model. Frontiers in Pediatrics. 2022 Oct 7.

Szocska Hansen ES , Bertelsen LB , Bøgh N , Miller J, Wohlfart P, Ringgaard S et al. Concentration-dependent effects of dichloroacetate in type 2 diabetic hearts assessed by hyperpolarized [1-¹³C]-pyruvate magnetic resonance imaging. NMR in Biomedicine. 2022 Jun;35(6):e4678. doi: 10.1002/nbm.4678

de Boer A, Villa G, Bane O, Bock M, Cox EF, Dekkers IA et al. Consensus-Based Technical Recommendations for Clinical Translation of Renal Phase Contrast MRI. Journal of Magnetic Resonance Imaging. 2022 Feb;55(2):323-335. Epub 2020 Nov 2. doi: 10.1002/jmri.27419

Joergensen SH , Hansen ESS , Bøgh N , Bertelsen LB, Staehr PB, Schulte RF et al. Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1- ¹³C]pyruvate cardiovascular magnetic resonance imaging. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. 2022 Jun;24:34. doi: 10.1186/s12968-022-00860-6

Hundt N, Cole D, Hantke MF, Miller JJ, Struwe WB, Kukura P. Direct observation of the molecular mechanism underlying protein polymerization. Science Advances. 2022 Sept;8(35):eabm7935. doi: 10.1126/sciadv.abm7935

Munk A , Duvald CS , Pedersen M , Lohmann S , Keller AK , Møller BK et al. Dosing Limitation for Intra-Renal Arterial Infusion of Mesenchymal Stromal Cells. International Journal of Molecular Sciences . 2022 Aug;23(15):8268. doi: 10.3390/ijms23158268

Ringgaard S, Hjortdal VE. Editorial for "Improved Tricuspid Valve Function, Preload Recruitment and Ventricular Efficiency During Submaximal Exercise in Patients With Unoperated Ebstein's Anomaly: An MRI Study". Journal of Magnetic Resonance Imaging. 2022 Jun;55(6):1851-1852. 27952. Epub 2021 Oct 7. doi: 10.1002/jmri.27952

Melgaard D, Sørensen J, Riis J, Ovesen TS, Leutscher P , Sørensen S et al. Efficacy of FODMAP Elimination and Subsequent Blinded Placebo‐Controlled Provocations in a Randomised Controlled Study in Patients with Ulcerative Colitis in Remission and Symptoms of Irritable Bowel Syndrome: A Feasibility Study. Nutrients. 2022 Mar;14(6):1296. doi: 10.3390/nu14061296

Lauridsen H, Thøstesen CB, Pedersen CCE , Ringgaard S, Steeman M, Møller PR et al. Heterochronic maturation of anatomical plugs for protecting the airway in rorqual whales (Balaenopteridae). Royal Society Open Science. 2022 Dec;9(12):1-7. 220459. doi: 10.1098/rsos.220459

Kirk FT , Munk DE, Ek J, Birk Møller L, Bendixen Thorup M , Hvid Danielsen E et al. Huppke-Brendel syndrome in an adult, mistaken for and treated as Wilson disease for 25 years: Case Report. Frontiers in Neurology. 2022 Sept;13:957794. doi: 10.3389/fneur.2022.957794

Andelius TCK , Hansen LH , Pinnerup R , Brogård Andersen H , Søvsø Szocska Hansen E , Bøgh N et al.. Hyperpolarized 13c magnetic resonance imaging after neonatal hypoxia-ischemia and therapeutic hypothermia; a newborn piglet model. 2022. Poster session presented at 9th Congress of the European Academy of Paediatric Societies, Barcelona , Spain.

Displaying results 1 to 20 out of 38

2021

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Funck KL , Laugesen E , Høyem P , Stausbøl-Grøn B , Kim WY , Østergaard L et al. Arterial stiffness and progression of cerebral white matter hyperintensities in patients with type 2 diabetes and matched controls: a 5-year cohort study. Diabetology & Metabolic Syndrome. 2021 Dec;13(1):71. doi: 10.1186/s13098-021-00691-y

Vaeggemose M, F Schulte R, Laustsen C. Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application. Metabolites. 2021 Apr;11(4):11. doi: 10.3390/metabo11040219

Mariager CØ , Hansen ESS , Bech SK , Eiskjær H , Nielsen PF , Ringgaard S et al. Development of a human heart-sized perfusion system for metabolic imaging studies using hyperpolarized [1-¹³C]pyruvate MRI. Magnetic Resonance in Medicine. 2021 Jun;85(6):3510-3521. doi: 10.1002/mrm.28639

Kerr M, Dennis KMJH, Carr CA, Fuller W, Berridge G, Rohling S et al. Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia. FASEB Journal. 2021 Aug;35(8):e21765. doi: 10.1096/fj.202100394R

Dwork N, Gordon JW, Tang S, O'Connor D, Hansen ESS , Laustsen C et al. Di-chromatic interpolation of magnetic resonance metabolic images. Magnetic Resonance Materials in Physics, Biology and Medicine. 2021 Feb;34(1):57-72. Epub 2021 Jan 27. doi: 10.1007/s10334-020-00903-y

Francis R, Chong J, Ramlall M, Bucciarelli-Ducci C, Clayton T, Dodd M et al. Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy. Basic Research in Cardiology. 2021 Dec;116(1):59. doi: 10.1007/s00395-021-00896-2

Langeskov-Christensen M , Grøndahl Hvid L , Nygaard MKE , Ringgaard S, Jensen HB, Nielsen HH et al. Efficacy of high-intensity aerobic exercise on brain MRI measures in multiple sclerosis. Neurology. 2021 Jan;96(2):e203-e213. Epub 2020 Dec 1. doi: 10.1212/WNL.0000000000011241

Burrage MK, Hundertmark M, Valkovič L, Watson WD, Rayner J, Sabharwal N et al. Energetic Basis for Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction. Circulation. 2021 Nov;144(21):1664-1678. doi: 10.1161/CIRCULATIONAHA.121.054858

Dam TV , Dalgaard LB, Thomsen CB, Hjortebjerg R , Ringgaard S , Johansen FT et al. Estrogen modulates metabolic risk profile after resistance training in early postmenopausal women: a randomized controlled trial. Menopause . 2021 Nov 1;28(11):1214-1224. doi: 10.1097/GME.0000000000001841

Rasmussen CW , Korsholm K , Kramer AD , Nielsen-Kudsk JE , Andersen A. Figure-of-eight suture combined with a three-way stopcock for venous closure following left atrial appendage occlusion or patent foramen ovale closure. Interventional Cardiology. 2021 Sept;13(6):392-399.

Hui SCN, Mikkelsen M, Zöllner HJ, Ahluwalia V, Alcauter S, Baltusis L et al. Frequency drift in MR spectroscopy at 3T. NeuroImage. 2021 Nov 1;241:118430. doi: 10.1016/j.neuroimage.2021.118430

Vaeggemose M , Mencagli RA , Hansen JS, Dräger B, Ringgaard S, Vissing J et al. Function, structure and quality of striated muscles in the lower extremities in patients with late onset Pompe Disease—an MRI study. PeerJ. 2021 May;9:e10928. doi: 10.7717/peerj.10928

Madsen JG , Skov MN , Hansen K , Laustsen C, Ejskjær N, Andersen H et al. Hyperbaric Oxygen Treatment for Diabetic Retinopathy and Neuropathy in a Streptozotocin Induced Diabetic Rat Model. Journal of Biomedical Science and Engineering. 2021 Dec;14(12):391-401. doi: 10.4236/jbise.2021.1412033

Bengtsen MB , Hansen ESS , Tougaard RS , Lyhne MD , Rittig NF , Støy J et al. Hyperpolarized [1- ¹³C]pyruvate combined with the hyperinsulinaemic euglycaemic and hypoglycaemic clamp technique in skeletal muscle in a large animal model. Experimental Physiology. 2021 Dec;106(12):2412-2422. Epub 2021 Oct 27. doi: 10.1113/EP089782

Bertelsen LB , Hansen ESS, Sadowski T, Ruf S, Laustsen C. Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney. NMR in Biomedicine. 2021 Nov;34(11):e4583. Epub 2021 Jul 8. doi: 10.1002/nbm.4583

Skotting MB , Eskildsen SF , Ovesen AS, Fonov VS, Ringgaard S , Hjortdal VE et al. Infants with congenital heart defects have reduced brain volumes. Scientific Reports. 2021 Dec;11(1):4191. doi: 10.1038/s41598-021-83690-3

Lildal SK , Søvsø Szocska Hansen E , Laustsen C, Sloth Osther PJ, Jung HU. Intrarenal backflow during endoluminal irrigation visualized by dynamic Gadolinium-enhanced MRI.. 2021. Abstract from Meeting of the Association of Academic European Urologists (AAEU)AAE.

Bøgh N, Olin RB, Søvsø Szocska Hansen E, Gordon JW, Bech SK , Bertelsen LB et al. Metabolic MRI with hyperpolarized [1-¹³C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke. Journal of Cerebral Blood Flow and Metabolism. 2021 Nov;41(11):2916-2927. Epub 2021. doi: 10.1177/0271678X211018317

Hyldebrandt JA, Bøgh N , Omann C , Agger P. Norepinephrine and dobutamine improve cardiac index equally by supporting opposite sides of the heart in an experimental model of chronic pulmonary hypertension. Intensive Care Medicine Experimental. 2021 Dec;9(1):29. doi: 10.1186/s40635-021-00391-x

Laustsen C. Renal MR Fingerprinting: A Novel Solution to a Complex Problem. Radiology. 2021 Aug;300(2):388-389. Epub 2021 Jun. doi: 10.1148/radiol.2021210924

Displaying results 1 to 20 out of 26

2020

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Brogård Andersen H , Andersen M , Andelius TCK , Pedersen MV , Løfgren B , Pedersen M et al.. Adrenaline versus placebo during resuscitation – the effect on ROSC and markers of CNS outcome; a newborn piglet model of hypoxic cardiac arrest. 2020. Poster session presented at 8th Congress of the European Academy of Paediatric Societies (virtuel).

Agger P , Omann C , Laustsen C , Stephenson RS, Anderson RH. Anatomically correct assessment of the orientation of the cardiomyocytes using diffusion tensor imaging. NMR in Biomedicine. 2020 Mar 1;33(3):e4205. doi: 10.1002/nbm.4205

Abood AAH , Møller-Madsen B , Shiguetomi Medina JM , Stødkilde-Jørgensen H , Foldager CB , Rahbek O. Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation: a pilot study in porcines. Journal of Children's Orthopaedics. 2020 Oct;14(5):459-465. doi: 10.1302/1863-2548.14.200024

Sánchez-Heredia JD, Baron R, Hansen ESS , Laustsen C, Zhurbenko V, Ardenkjaer-Larsen JH. Autonomous cryogenic RF receive coil for ¹³C imaging of rodents at 3 T. Magnetic Resonance in Medicine. 2020 Jul 1;84(1):497-508. Epub 2019 Nov. doi: 10.1002/mrm.28113

Bøgh N , Søvsø Szocska Hansen E , Østergaard Mariager C , Bertelsen LB , Ringgaard S , Laustsen C. Cardiac pH-Imaging With Hyperpolarized MRI. Frontiers in Cardiovascular Medicine. 2020 Nov 5;7:603674. doi: 10.3389/fcvm.2020.603674

Wichmann TO , Pedersen M , Ringgaard S , Rasmussen MM. Cerebrospinalvæskens flowdynamik og fasekontrast-MR-skanning ved syringomyeli. Ugeskrift for Læger. 2020;182(22):V12190730.

Nery F, Buchanan CE, Harteveld AA, Odudu A, Bane O, Cox EF et al. Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magnetic Resonance Materials in Physics, Biology and Medicine. 2020 Feb;33(1):141-161. Epub 2019 Dec 12. doi: 10.1007/s10334-019-00800-z

Bane O, Mendichovszky IA, Milani B, Dekkers IA, Deux JF, Eckerbom P et al. Consensus-based technical recommendations for clinical translation of renal BOLD MRI. Magnetic Resonance Materials in Physics, Biology and Medicine. 2020;33(1):199-215. Epub 2019 Nov 25. doi: 10.1007/s10334-019-00802-x

Ljimani A, Caroli A, Laustsen C, Francis S, Mendichovszky IA, Bane O et al. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI. Magnetic Resonance Materials in Physics, Biology and Medicine. 2020;33(1):177-195. Epub 2019 Nov 1. doi: 10.1007/s10334-019-00790-y

Dekkers IA, de Boer A, Sharma K, Cox EF, Lamb HJ, Buckley DL et al. Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI. Magnetic Resonance Materials in Physics, Biology and Medicine. 2020 Feb 1;33(1):163–176. Epub 2019 Nov. doi: 10.1007/s10334-019-00797-5

Grist JT, Hansen ESS, Sánchez-Heredia JD, McLean MA, Tougaard R, Riemer F et al. Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances. Magnetic Resonance in Medicine. 2020 Oct 1;84(4):1817-1827. Epub 2020 Mar 13. doi: 10.1002/mrm.28238

Grist JT, Mariager CØ , Qi H , Nielsen PM , Laustsen C. Detection of acute kidney injury with hyperpolarized [¹³C, ¹⁵N]Urea and multiexponential relaxation modeling. Magnetic Resonance in Medicine. 2020 Aug 1;84(2):943-949. doi: 10.1002/mrm.28134

Vaeggemose M , Haakma W, Pham M, Ringgaard S , Tankisi H, Ejskjaer N et al. Diffusion tensor imaging MR Neurography detects polyneuropathy in type 2 diabetes. Journal of Diabetes and its Complications. 2020 Feb;34(2):107439. doi: 10.1016/j.jdiacomp.2019.107439

Maagaard M , Eckerström F , Heiberg J , Asschenfeldt B , Ringgaard S , Hjortdal VE. Disappearance of the shunt and lower cardiac index during exercise in small, unrepaired ventricular septal defects. Cardiology in the Young. 2020 Apr 1;30(4):526-532. Epub 2020 Mar 25. doi: 10.1017/S1047951120000505

Riis-Vestergaard MJ , Laustsen C , Mariager CØ, Schulte RF, Pedersen SB , Richelsen B. Glucose metabolism in brown adipose tissue determined by deuterium metabolic imaging in rats. International journal of obesity (2005). 2020 Jun 1;44(6):1417-1427. Epub 2020 Jan 21. doi: 10.1038/s41366-020-0533-7

Mariager CØ , Hansen ESS , Bech SK , Munk A , Kjærgaard U , Lyhne MD et al. Graft assessment of the ex vivo perfused porcine kidney using hyperpolarized [1-¹³C]pyruvate. Magnetic Resonance in Medicine. 2020 Nov 1;84(5):2645-2655. doi: 10.1002/mrm.28363

Pedersen M, Ursprung S, Jensen JD , Jespersen B, Gallagher F, Laustsen C. Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality. Magnetic Resonance Materials in Physics, Biology and Medicine. 2020;33(1):23-32. Epub 2019 Nov 28. doi: 10.1007/s10334-019-00801-y

Andelius TCK , Søvsø Szocska Hansen E , Bøgh N , Pedersen MV , Kyng KJ , Henriksen TB et al.. Hyperpolarized 13c magnetic resonance spectroscopy and hypoxic ischemic encephalopathy – proof of concept in a piglet model. 2020. Abstract from 8th Congress of the European Academy of Paediatric Societies.

Grist JT, Miller JJ, Zaccagna F, McLean MA, Riemer F, Matys T et al. Hyperpolarized 13C MRI: A novel approach for probing cerebral metabolism in health and neurological disease. Journal of Cerebral Blood Flow and Metabolism. 2020 Jun 1;40(6):1137-1147. doi: 10.1177/0271678X20909045

Laustsen C , Nielsen PM , Qi H , Løbner MH , Palmfeldt J , Bertelsen LB. Hyperpolarized [1,4-¹³C]fumarate imaging detects microvascular complications and hypoxia mediated cell death in diabetic nephropathy. Scientific Reports. 2020 Dec;10:9650. doi: 10.1038/s41598-020-66265-6

Displaying results 1 to 20 out of 42

2019 and earlier publications

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Omann C , Lauridsen MH , Ringgaard S , Karunanithi Z , Hjortdal VE. Abstract 13336: Placental Oxygenation in Fetuses With and Without a Heart Defect. Circulation. 2019 Nov;140(Suppl. 1):A13336-A13336. doi: 10.1161/circ.140.suppl_1.13336

Juul KV, Schrøder MK , Mahler B , Rittig S, Nørgaard JP. A Danish population-based cohort study of desmopressin use in adults with nocturia or nocturnal enuresis. Lower urinary tract symptoms. 2019;11(2):O121-O126. doi: 10.1111/luts.12229

Abulizi A, Camporez JP, Jurczak MJ, Høyer KF, Zhang D, Cline GW et al. Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action. F A S E B Journal. 2019 Jul;33(7):8174-8185. doi: 10.1096/fj.201802706R

Rasmussen DGK, Nielsen PM, Kasab-Oglo OY, Nielsen SH, Kierulf-Lassen C, Karsdal MA et al. A non-invasive biomarker of type III collagen degradation reflects ischaemia reperfusion injury in rats. Nephrology Dialysis Transplantation. 2019 Aug;34(8):1301-1309. doi: 10.1093/ndt/gfy345

Mortensen KH , Wen J , Erlandsen M , Trolle C , Ringgaard S, Gutmark EJ et al. Aortic growth rates are not increased in Turner syndrome-a prospective CMR study. European Heart Journal Cardiovascular Imaging. 2019 Oct;20(10):1164-1170. Epub 2019 Apr. doi: 10.1093/ehjci/jez065

Faarkrog Høyer K , Laustsen C , Ringgaard S , Qi H , Mariager CØ, Nielsen TS et al. Assessment of mouse liver [1-¹³C]pyruvate metabolism by dynamic hyperpolarized MRS. Journal of Endocrinology. 2019 Sept;242(3):251-260. Epub 2019 Jul 1. doi: 10.1530/JOE-19-0159

Lauridsen H, Desvignes T, Damsgaard C , Thomsen JS, Stenum T, Ringgaard S et al. Bone mineral density reduction explains buoyancy adaptations in notothenioids. F A S E B Journal. 2019;33(1).

Obelitz-Ryom K, Bering SB, Overgaard SH, Eskildsen SF , Ringgaard S , Olesen JL et al. Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs. Nutrients. 2019 Jun 14;11(6):1335. doi: 10.3390/nu11061335

Boutrup NJ , Udholm S , Ringgaard S , Hjortdal VE. Cardiac magnetic resonance imaging in adults with small unrepaired atrial septal defects. 2019. Abstract from 29th Annual Meeting SSRCTS, Geilo, Norway.

Boutrup NJ , Udholm S , Ringgaard S , Hjortdal VE. Cardiac magnetic resonance imaging in adults with small unrepaired atrial septal defects. World Journal for Pediatric and Congenital Heart Surgery. 2019;10(2):NP36.

Boutrup NJ , Udholm S , Ringgaard S , Hjortdal VE. Cardiac magnetic resonance imaging in adults with small unrepaired atrial septal defects. 2019. Poster session presented at 22nd Annual Update on Pediatric and Congenital Cardiovascular Disease, California, United States.

Hansen RB, Sánchez-Heredia JD, Bøgh N , Hansen ESS , Laustsen C, Hanson LG et al. Coil profile estimation strategies for parallel imaging with hyperpolarized 13 C MRI. Magnetic Resonance in Medicine. 2019 Dec;82(6):2104-2117. Epub 2019 Jul 11. doi: 10.1002/mrm.27892

Østergaard Mariager C , Søvsø Szocska Hansen E , Bech SK , Munk A , Lyhne MD, Søberg K et al.. Comparison of perfusion markers in the ex-vivo perfused porcine kidney: hyperpolarized [1-13C]pyruvate versus gold standard 1H DCE MRI. 2019. Abstract from ESMRMB 2019, Rotterdam, Netherlands.

Egekvist AG , Marinovskij E , Forman A, Kesmodel US, Graumann O, Seyer-Hansen M. Conservative treatment of rectosigmoid endometriosis: a prospective study. Acta Obstetricia et Gynecologica Scandinavica. 2019 Sept;98(9):1139-1147. Epub 2019 Apr 10. doi: 10.1111/aogs.13619

Andersen M , Andelius TCK , Pedersen MV , Brogård Andersen H , Pedersen M , Ringgaard S et al.. Correlation between insult severity and early MRI/MRS measures in hypothermia treated newborn piglets with hypoxic ischemic encephalopathy. 2019. Poster session presented at Third Congress of joint European Neonatal Societies.

Østergaard Mariager C , Søvsø Szocska Hansen E, Bech SK, Nielsen PF, Ringgaard S , Kimose HH et al. Development of a human heart sized perfusion system for metabolic imaging studies using hyperpolarized [1-13C]pyruvate MRI. In ISMRM 2019. 2019

Maagaard MØ , Eckerström FCA , Heiberg J , Arlander BA , Ringgaard S , Hjortdal VE. Disappearance of the shunt in small, unrepaired ventricular septal defects during exercise. 2019. Poster session presented at 22nd Annual Update on Pediatric and Congenital Cardiovascular Disease, California, United States.

Maagaard MØ , Eckerström FCA , Heiberg J , Arlander BA , Ringgaard S , Hjortdal VE. Disappearance of the shunt in small, unrepaired ventricular septal defects during exercise. World Journal for Pediatric and Congenital Heart Surgery. 2019;10(2):NP13.

Brogård Andersen H , Andersen M , Andelius TCK , Pedersen MV , Pedersen M , Ringgaard S et al.. Effect of adrenaline on survival and neurological outcome in a newborn piglet model of hypoxic cardiac arrest. 2019. Abstract from 3rd Annual Research Meeting 2019, Aarhus, Denmark.

Axelsen JB , Andersen S, Sun XQ, Ringgaard S , Hyldebrandt JA, Kurakula K et al. Effects of 6-mercaptopurine in pressure overload induced right heart failure. PLoS One. 2019 Nov 1;14(11):e0225122. doi: 10.1371/journal.pone.0225122

Displaying results 1 to 20 out of 684

Revised 23.10.2025

Maria Ditlev